Dopamine mediated iron release from ferritin is enhanced at higher temperatures : Possible implications for fever-induced Parkinson's disease
Identifieur interne : 002B31 ( Main/Exploration ); précédent : 002B30; suivant : 002B32Dopamine mediated iron release from ferritin is enhanced at higher temperatures : Possible implications for fever-induced Parkinson's disease
Auteurs : Melania Babincova [Slovaquie] ; Peter Babinec [Slovaquie]Source :
- Journal of magnetism and magnetic materials [ 0304-8853 ] ; 2005.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Fer.
English descriptors
- KwdEn :
Abstract
A new molecular mechanism is proposed to explain the pathogenesis of fever-induced Parkinson's disease. This proposal is based on dopamine and 6-hydroxydopamine-mediated free iron release from ferritin magnetic nanoparticles, which is enhanced at higher temperatures, and which may lead to substantial peroxidation and injury of lipid biomembranes of the substantia nigra in the brain.
Affiliations:
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Le document en format XML
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